Short-term melatonin is a well-tolerated treatment for sleep disturbance in youth with PPCS following mTBI. Changes in cognition or behavior were otherwise not significantly different between treatment groups. Depressive symptoms significantly decreased with melatonin 3 mg (-4.7 95% CI: −9.2, −.2) but not with melatonin 10 mg (−1.4, 95% CI: −5.9, 3.2) treatment compared with placebo.
A per protocol analysis demonstrated improved sleep efficiency in the melatonin 10 mg group ( p = 0.029). About Me Open All X Cookies help us improve your website experience. Sleep duration increased in the melatonin 3 mg (43 min 95% CI: 6, 93) and melatonin 10 mg groups (55 min 95% CI: 5, 104) compared with placebo. MacMaster, MD, PA 8220 Walnut Hill Lane Ste 310 Dallas, TX 75231 Location Website Hospital Affiliations Texas Health Dallas Call today to make an appointment 21 Not Available for Video Visits. SRPs decreased across all groups over time with a significant effect of melatonin 3 mg (3.7 95% confidence interval : 2.1, 5.4) compared with placebo (7.4 95% CI: 4.2, 10.6) and melatonin 10 mg (6.4 95% CI: 3.6, 9.2). Sixty-four participants had actigraphy data. Seventy-two participants (mean age 14.0, standard deviation = 2.6) years 60% female) with PPCS and significant sleep disturbance were included in the secondary analysis: placebo ( n = 22) melatonin 3 mg ( n = 25) melatonin 10 mg ( n = 25). Behavior was measured using Behaviour Assessment for Children (2nd edition). Secondary outcomes included change in actigraphy sleep efficiency, duration, onset latency, and wake-after-sleep-onset. Primary outcome was change in SRPs measured using the Post-Concussion Symptom Inventory (PCSI) after 2 weeks of treatment. Treatment groups were: placebo, melatonin 3 mg, or melatonin 10 mg. Exclusion criteria: significant medical/psychiatric history previous concussion/mTBI within 3 months. I use Apple Mac, shoot my movies with Lumix GH5, Sony A7 III, iPhone 13 Mini. Youth (8–18 years of age) with PPCS and significant sleep-related problems (SRPs) at 4–6 weeks post-injury were eligible. I make vlogs about TRAVEL, FOOD and TECH.
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This article is a secondary analysis of a clinical trial of melatonin compared with placebo to treat PPCS. We aimed to evaluate the efficacy of treatment with melatonin for sleep disturbance in youth with PPCS following mild traumatic brain injury (mTBI).
Melatonin treatment is often recommended, yet supporting evidence is scarce. Sleep disturbances are commonly reported in children with persistent post-concussion symptoms (PPCS).
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